Search results for "Erythrocyte fragility"

showing 3 items of 3 documents

Epidemiological, biological and clinical update on exercise-induced hemolysis

2019

Exercise-induced hemolysis can be conventionally defined as rupture and destruction of erythrocytes during physical exercise. The currently available epidemiologic information attests that a substantial degree of exercise-induced hemolysis is commonplace after short-, medium-, long- and ultra-long distance running, as reflected by significant decrease of serum or plasma haptoglobin and significant increase of plasma concentration (or overall blood content) of free hemoglobin. This paraphysiological intravascular hemolysis is typically mild (average variations of hemolysis biomarkers are usually comprised between 1.2- and 1.8-fold), almost self-limiting (completely resolving within 24-48 hou…

medicine.medical_specialtyPopulationPhysical exerciseReview Article030204 cardiovascular system & hematologyExercise-induced hemolysisHemolysis03 medical and health sciences0302 clinical medicinephysical exerciseEndurance trainingInternal medicinemedicineHemolysis; hemoglobin; red blood cells (RBC); sports physical exerciseeducationeducation.field_of_studyred blood cells (RBC)biologybusiness.industryHaptoglobinErythrocyte fragility030229 sport sciencesGeneral Medicinehemoglobinmedicine.diseaseHemolysisHypotonic ShockEndocrinologybiology.proteinsportsbusinessAnnals of Translational Medicine
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Erythrocyte deformability, plasma lipid peroxidation and plasma protein oxidation in a group of OSAS subjects

2016

Considering that obstructive sleep apnea syndrome (OSAS) is usually associated with endothelial dysfunction, atherosclerosis and cardiovascular disorders, our aim was to examine the erythrocyte deformability and the oxidative status in a group of OSAS subjects. We consecutively enrolled 48 subjects with OSAS defined after a 1-night cardiorespiratory sleep study, subsequently subdivided according to the apnea/hypopnea index (AHI) value in two subgroups: Low (L = 21 subjects with AHI30) and High (H = 27 subjects with AHI30). We evaluated the erythrocyte deformability, expressed as elongation index (EI) and the parameters of the oxidative status, such as lipid peroxidation (expressed as thioba…

Malemedicine.medical_specialtyPhysiologyLipid peroxidation030204 cardiovascular system & hematologymedicine.disease_causeProtein oxidationBioinformaticsLipid peroxidation03 medical and health scienceschemistry.chemical_compound0302 clinical medicineBlood Proteinstomatognathic systemErythrocyte DeformabilityPhysiology (medical)Internal medicineErythrocyte deformability; Lipid peroxidation; OSAS; Protein oxidation; Blood Proteins; Erythrocyte Deformability; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Sleep Apnea Obstructive; Physiology; Hematology; Cardiology and Cardiovascular Medicine; Physiology (medical)medicineTBARSHumansErythrocyte deformabilitySleep Apnea Obstructivebusiness.industryErythrocyte fragilityOSASOxidative StreBlood ProteinsHematologyMiddle Agedmedicine.diseaseBlood proteinsnervous system diseasesrespiratory tract diseasesOxidative StressEndocrinology030228 respiratory systemchemistryFemaleCardiology and Cardiovascular MedicinebusinessProtein oxidationOxidation-ReductionHypopneaOxidative stressHumanClinical Hemorheology and Microcirculation
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Protective effect of melatonin against cytotoxic actions of malondialdehyde: an in vitro study on human erythrocytes

2002

Malondialdehyde (MDA), a by-product of the oxidation of polyunsaturated fatty acids, is strongly cytotoxic. Here we report the in vitro ability of melatonin to protect intact human erythrocytes against the damage induced by the exposure to MDA. MDA at 20 microM caused marked variations in the red blood cell (RBC) membrane. High molecular weight fluorescent adducts were formed within minutes with membrane proteins. A 6-hr incubation led to the oxidation of membrane lipids, as reflected by the formation of conjugated diene (CD) lipid hydroperoxides and oxidation of vitamin E, and to an increase of the high molecular weight fluorescent adducts, which were an indication of MDA finally generated…

Membrane lipidsVitamin Emedicine.medical_treatmentErythrocyte fragilityBiologyMalondialdehydeMelatoninchemistry.chemical_compoundRed blood cellEndocrinologymedicine.anatomical_structureBiochemistrychemistryLipid oxidationMembrane proteinmedicinemedicine.drugJournal of Pineal Research
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